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We recognize the importance of ensuring appropriate payment pathways for innovative treatments that may be administered during dialysis but fall outside the definition of a renal dialysis service under 413.171 and thus are not paid for under the ESRD PPS

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229 Specifically, PKA modifies the open state of K-ATP channels through phosphorylation, affecting the cell membranes potential and intracellular calcium ion concentration

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It interferes with the absorption of the B12intrinsic factor complex in the terminal ileum